TMCB
selective CK2 inhibitor（选择性CK2抑制剂）
Purity: >98%
Biological Description
CK2 inhibitor (Ki = 0.25 μM), more selective than DMAT. Unlike DMAT, TMCB displays selectivity over PIM1, HIPK2 and DYRK1a (Ki values are 8.65, 15.25 and 11.90 μM respectively) and a more favourable selectivity profile over a range of other kinases.
Useful References
Pagona et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 415:353-65 abstract
Chemical Information
2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
