• 产品编号:Asc-193
    • 产品名称:UBP141
    • 产品规格:10mg
    • 价  格:1680.00
    • 供 应 商:Ascent
    • 库  存:
  • UBP141

    GluN2D (formerly NR2D) antagonist, with some subunit selectivity
    Purity: >98%

    Biological Description
    GluN2D (formerly NR2D) antagonist, displaying modest GluN2 (NR2) subunit selectivity. Shows 7-fold selectivity for GluN2D (NR2D)-containing NMDA receptors vs GluN2B (NR2B) and 5-fold selectivity over GluN2A (NR2A ) but does not discriminate between GluN2C (NR2C) and GluN2D (NR2D). Ki values are 22, 17.2, 5.24 and 2.36 μM for NR1/2A, NR1/2B, NR1/2C and NR1/2D receptors respectively.

    Useful References
    Morley et al (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 48:2627-37 abstract

    Brothwell et al (2008) NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol. 586:739-50 abstract

    Costa et al (2009) NMDA receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives; preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. JPET (In Press).



    Our products in action...
    Banerjee et al. (2009) Double Dissociation of Spike Timing–Dependent Potentiation and Depression by Subunit-Preferring NMDA Receptor Antagonists in Mouse Barrel Cortex. Cerebral Cortex abstract

     


    Chemical Information
    (2R*,3S*)-1-(Phenanthrenyl-3-carbonyl)piperazine-2,3-dicarboxylic acid
     


     

    • Desiccate at +4°C
    • MW 378.38
    • Soluble to 50 mM in 2eq. NaOH with warming (keep solution frozen for up to 1 week)
    • C21H18N2O5