• 产品编号:Asc-047
    • 产品名称:cis-PPDA/cis-苯磷酸二酰胺
    • 产品规格:10mg/50mg
    • 价  格:1710.00/6240.00
    • 供 应 商:Ascent
    • 库  存:
  • cis-PPDA

     GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist
    Purity: >98%

    Biological Description
    Potent GluN2C/GluN2D (formerly NR2C / NR2D)-preferring NMDA receptor antagonist. Ki values are 0.096 μM, 0.125 μM, 0.55 μM and 0.31 μM for recombinant rat NR2C, NR2D, NR2A and NR2B receptors respectively.

    Useful References
    Lozovaya et al (2004) Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape superslow afterburst EPSC in rat hippocampus.J.Physiol. 558:451 abstract

    Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313:1066 abstract

    Morley et al (2004) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 48:2627-37 abstract



    Chemical Information
    (2R*,3S*)-1-(Phenanthrenyl-2-carbonyl)piperazine-2,3-dicarboxylic acid
     
     

    • Desiccate at +4°C
    • MW 378.38
    • Soluble to 50 mM in 2eq. NaOH with warming (keep solution frozen for up to 1 week)
    • C21H18N2O5

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