DL-AP5
NMDA glutamate site antagonist （NMDA谷氨酸盐位点拮抗剂）
Purity: >99%
Biological Description
Competitive NMDA receptor glutamate site antagonist. Water-soluble form available - please see DL-AP5 sodium salt (#Asc-271).
Useful References
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65.
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235:378.
Watkins and Evans (1981) Excitatory amino acid transmitters. Ann. Rev. Pharmacol. Toxicol. 21:165
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Oren et al. (2009) Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons. J Neurosci 29(4):939-950 abstract
Urbanski et al. (2009) Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. Synapse. 63(8):643-52. abstract
Chemical Information
DL-(-)-2-Amino-5-phosphonopentanoic acid
