D-AP5
NMDA glutamate site antagonist （NMDA谷氨酸盐位点拮抗剂）
Purity: >99%
Biological Description
Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.
Useful References
Kew and Kemp (2005) Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacol. 179:4
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65.
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235:378
Our products in action...
Bardoni et al. (2007) BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats. Dev Neurobiol. 67:960-75. abstract
Trigo et al. (2007) Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum. J Neurosci. 27:12452-63. abstract
Chemical Information
D-(-)-2-Amino-5-phosphonopentanoic acid
