• 产品编号:Asc-040
    • 产品名称:(S)-Willardiine
    • 产品规格:10mg/50mg
    • 价  格:1710.00/7050.00
    • 供 应 商:Ascent
    • 库  存:
  • (S)-Willardiine

    AMPA / kainate receptor agonist (AMPA/红藻氨酸受体拮抗剂)
    Purity: >98%

    Biological Description
    selective AMPA receptor agonist at hGluR1 (Ki = 0.39 μM). selective over hGluR2 (Ki = 0.90 μM), hGluR4 (Ki = 8.85 μM) and kainate receptor hGluR5 (Ki = 28.9 μM). Produces strong desensitisation.

    Useful References
    Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12:595-606 abstract

    Hawkins et al (1995) Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine. Neuropharmacol. 34:405-410 abstract

    Stensbol et al (2002) The AMPA receptor binding site: focus on agonists and competitive antagonists. Curr.Pharm.Design 8:857-872 abstract

    Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem 40: 3645-50 abstract


    Our products in action...
    Mankiewicz et al (2008) Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Biochemistry. 47:398-404. abstract

     


    Chemical Information
    (S)-2-Amino-3-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)propanoic acid
     


     

    • Desiccate at +4°C
    • MW 199.17
    • Soluble to 50 mM in 1.1eq. NaOH (keep solution frozen for up to 1 week)
    • C7H9N3O4
    • 21416-43-3


     

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