• 产品编号:Asc-542
    • 产品名称:α-Bungarotoxin
    • 产品规格:1mg
    • 价  格:1710.00
    • 供 应 商:Ascent
    • 库  存:
  • α-Bungarotoxin                Subtype-selective α7 nAChR antagonist

    Purity: >99%

    Biological Description

    Irreversible antagonist of nicotinicαacethylcholine receptors (nAChRs). 74-aa polypeptide derived from the venom of the banded krait, Bungarus multicinctus. Selective for α7 receptors over α3α4 receptors (IC50 values are 1.6 nM and > 3 μM respectively). Blocks neuromuscular transmission. Inhibits opening of nicotinic receptor-associated ion channels.

    Useful References

    Gotti et al (2004) Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol. 74(6):363-96. abstract

    Colquhoun et al (1997) Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol. 39:191-220. abstract

    Marinou et al (2003) Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides. Biochem J. 372(Pt 2):543-54. abstract

     

    Chemical Information

    IVCHTTATSPISAVTCPPGENLCYRKMWCDA FCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG disulfide bridges 3-23, 16-44, 29-33, 48-59, 60-65

    Asc-542
    • Desiccate at -20°C
    • MW 7984.14
    • Soluble in any aqueous buffer
    • C338H529N97O105S11
    • 11032-79-4