S 24795            Partial α7 nAchr agonist

Purity: >99%

Biological Description Partial α7 nAchr agonist (EC50 = 34 μM). Alleviates memory impairments, improving contextual memory. Displays greater memory enhancement effect than Memantine (Asc-249). Disrupts Amyloid α/ α7 nAchr interaction to reduce Alzheimers disease-like pathologies.
Useful References Lopez-Hernandez et al (2007) Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAchr responses of hippocampal interneurons. Neuropharmacology. 53(1):134-44. abstract Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology (Berl). 196(4):555-64. abstract Wang et al (2009) Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimers disease brain. J Neurosci. 29(35):10961-73. abstract
Chemical Information 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
	Store at +4°C MW 418.07 Soluble in DMSO to 100 mm and water to 10mM (requires warming) C14H13BrINO 304679-75-2