• 产品编号:Asc-553
    • 产品名称:S 24795
    • 产品规格:10mg/50mg
    • 价  格:1260.00/5130.00
    • 供 应 商:Ascent
    • 库  存:
  • S 24795            Partial α7 nAchr agonist

    Purity: >99%

    Biological Description

    Partial α7 nAchr agonist (EC50 = 34 μM). Alleviates memory impairments, improving contextual memory. Displays greater memory enhancement effect than Memantine (Asc-249). Disrupts Amyloid α/ α7 nAchr interaction to reduce Alzheimers disease-like pathologies.

    Useful References

    Lopez-Hernandez et al (2007) Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAchr responses of hippocampal interneurons. Neuropharmacology. 53(1):134-44. abstract

    Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology (Berl). 196(4):555-64. abstract

    Wang et al (2009) Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimers disease brain. J Neurosci. 29(35):10961-73. abstract

     

    Chemical Information

    2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide

    Asc-553 S 24795
    • Store at +4°C
    • MW 418.07
    • Soluble in DMSO to 100 mm and water to 10mM (requires warming)
    • C14H13BrINO
    • 304679-75-2