• 产品编号:Asc-569
    • 产品名称:Pramipexole dihydrochloride/盐酸普拉克索
    • 产品规格:10mg/50mg
    • 价  格:1200.00/4950.00
    • 供 应 商:Ascent
    • 库  存:
  • Pramipexole dihydrochloride          Dopamine D2-like receptor agonist. D3-preferring.

    Purity: >99%

    Biological Description

    Dopamine D2-like receptor agonist showing some selectivity for D3 (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Potent anti-oxidant. Displays anti-depressant and anti-Parkinsonian effects.

    Useful References

    Newman-Tancredi et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharmacol Exp Ther. 303:805-14. abstract

    Ling et al (1999) Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. 289:202-10. abstract

    Mierau et al (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 290(1):29-36. abstract

     

    Chemical Information

    (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride

    Asc-569 Pramipexole dihydrochloride
    • Desiccate at +4°C
    • MW 284.25
    • Soluble in water to 100mM
    • C10H17N3S.2HCl
    • 104632-25-9

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