Pramipexole dihydrochloride          Dopamine D₂-like receptor agonist. D₃-preferring.

Purity: >99%

Biological Description Dopamine D2-like receptor agonist showing some selectivity for D3 (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Potent anti-oxidant. Displays anti-depressant and anti-Parkinsonian effects.
Useful References Newman-Tancredi et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharmacol Exp Ther. 303:805-14. abstract Ling et al (1999) Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. 289:202-10. abstract Mierau et al (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 290(1):29-36. abstract
Chemical Information (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
	Desiccate at +4°C MW 284.25 Soluble in water to 100mM C10H17N3S.2HCl 104632-25-9