• 产品编号:Asc-486
    • 产品名称:Cromakalim/克罗卡林
    • 产品规格:10mg/50mg
    • 价  格:1740.00/7470.00
    • 供 应 商:Ascent
    • 库  存:
  • Cromakalim                  KIR6.x (KATP) channel activator

    Purity: >99%

    Biological Description

    KIR6.x (KATP) channel activator. Orally active, potent smooth muscle relaxant.

    Useful References

    Cecchetti et al (2006) From cromakalim to different structural classes of K(ATP) channel openers. Curr Top Med Chem. 6(10):1049-68. abstract

    Atwal (1994) Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 24:S12-7. abstract

    Quast et al (1989) In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide. J Pharmacol Exp Ther. 250(1):261-71. abstract

     

    Chemical Information

    (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

    Asc-486 Cromakalim
    • Desiccate at +4°C
    • MW 286.33
    • Soluble in DMSO to 50 mM
    • C16H18N2O3
    • 94470-67-4

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