CGS 21680                    Potent, selective A_2A agonist

Purity: >98%

Biological Description Potent, selective A2A agonist (Ki = 23 nM). Hypotensive in vivo. Also delays motor performance deterioration and prevents reduction of brain weight in Huntingtons disease model.
Useful References Hutchison et al (1989 ) CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther. 251:47-55. abstract Chou et al (2005) CGS21680 attenuates symptoms of Huntingtons disease in a transgenic mouse model. J Neurochem. 93:310-20. abstract Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 362:382-91. abstract
Chemical Information 2-p-(2-Carboxyethyl)phenethylamino-5-N-ethylcarboxamidoadenosine hydrochloride
	Desiccate at -20°C MW 535.99 Soluble in DMSO to 100 mM C23H29N7O6.HCl 124182-57-6