Bromocriptine mesylate                   Potent, selective D₂-like dopamine receptor agonist 

Purity: >99%

Biological Description Potent, selective D2-like dopamine receptor agonist (Ki values are ~8, ~5, ~290, ~440 and ~450 nM for D2, D3, D4, D1 and D5 receptors respectively). Inhibits the release of pituitary prolactin and stimulates motor activity in Parkinsons disease. Also reverses glutamate transporter 1 (GLT-1) activity, increasing glutamate levels.
Useful References Seeman et al (1994) Dopamine receptor pharmacology. Trends Pharmacol Sci. 15:264-70. abstract Valente et al (1997) Metabolite involvement in bromocriptine-induced prolactin inhibition in rats. J Pharmacol Exp Ther. 282:1418-24. abstract Shirasaki et al (2010) Bromocriptine, an ergot alkaloid, inhibits excitatory amino acid release mediated by glutamate transporter reversal. Eur J Pharmacol. 643:48-57. abstract Lindgren et al (2009) Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinsons disease. Neuropsychopharmacology. 34:247 abstract
Chemical Information (5α)-2-Bromo-12-hydroxy-2-(1-methylethyl)-5-(2-methylpropyl)ergotaman-3,6,18-trione methanesulfonate
	Store at +4°C MW 750.7 Soluble in DMSO to 100 mM and in ethanol to 25 mM (with heating) C32H40BrN5O5.CH3SO3H 22260-51-1