SB-277011-A dihydrochloride               Potent, highly selective D₃ antagonist 

Purity: >98%

Biological Description Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug taking behaviours.
Useful References Thanos et al (2008) The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. Pharmacol Biochem Behav. 89:499-507. abstract Thanos et al (2005) The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats. Pharmacol Biochem Behav. 81:190-7. abstract Ross et al (2007) Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats. Eur J Pharmacol. 559:173-9. abstract
Chemical Information N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
	Desiccate at +4°C MW 511.49 Soluble in water to 10 mM, in ethanol to 10 mM and in DMSO to 100 mM C28H30N4O.2HCl 1226917-67-4