Domperidone              Peripheral D₂-like receptor antagonist

Purity: >99%

Biological Description Peripheral D2-like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.
Useful References Barone (1999) Domperidone: a peripherally acting dopamine2-receptor antagonist. Ann Pharmacother. 33:429-40. abstract Reddymasu et al (2007) Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 102:2036-45. abstract Takahashi et al (1991) Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs. Gastroenterology. 101(3):703-10. abstract
Chemical Information 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
	Store at RT MW 425.92 Soluble in DMSO to 100 mM C22H24ClN5O2 57808-66-9