• 产品编号:Asc-554
    • 产品名称:HC-030031
    • 产品规格:10mg/50mg
    • 价  格:888.00/3608.00
    • 供 应 商:Ascent
    • 库  存:
  • HC-030031               TRPA1 blocker, orally active

    Purity: >99%

    Biological Description

    selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.

    Useful References

    Eid et al (2008) HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 4:48. abstract

    McNamara et al (2007) TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 104(33):13525-30. Epub 2007 Aug 8. abstract

    Ro et al (2009) Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. Pain. 144(3):270-7. Epub 2009 May 22. abstract

     

    Chemical Information

    2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

    Asc-554 HC-030031
    • Store at RT
    • MW 355.39
    • Soluble in DMSO to 100 mM
    • C18H21N5O3
    • 349085-38-7