LY 272015 hydrochloride               Highly potent, selective 5-HT_2B antagonist 

Purity: >99%

Biological Description Highly potent, selective 5-HT2B receptor antagonist (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Displays anti-hypertensive activity in vivo.
Useful References Russell et al (2002) 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. J Pharmacol Exp Ther. 303:179-87. abstract Watts et al (1999) 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 276:944-52. abstract Audia et al (1996) Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J Med Chem. 39:2773-80. abstract
Chemical Information 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
	Store at +4°C MW 372.89 Soluble in DMSO to 100 mM C21H24N2O2.HCl 172895-15-7