• 产品编号:NA-AH6-1
    • 产品名称:Natural Ara h 6 (NA-AH6-1)
    • 产品规格:250μg
    • 价  格:9200.00
    • 供 应 商:Indoor
    • 库  存:
  • Allergen: nAra h 6 (Arachis hypogaea allergen 6)
    Unit: 250μg
    Source: Light roasted peanut flour (Runner cultivar)
    Mol. Wt: 14.5 kD
    Purification:

    From delipidated peanut extract by multi-step chromatography. Purity on silver stained SDS-PAGE >90%.

    Concentration: See Product insert. Based on Advanced Protein Assay (Cytoskeleton, Inc., Denver, CO)
    Formulation:

    Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.

    Storage: Store at -20oC
    Notes:

    Trace Ara h 1 and Ara h 2 levels <0.05%

    PDB:  
    Product Resources: Natural Ara h 6 Certificate of Analysis
    Related products:  
    For Research Use Only: Not for Diagnostic or Therapeutic Use
    References:  

    Kleber-Janke T, Crameri R, Appenzeller U, Schlaak M, Becker WM. selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol 1999; 119: 265-74.

    Suhr M, Wicklein D, Lepp U, Becker W. Isolation and characterization of natural Ara h 6: Evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat. Mol Nutr Food Res 2004; 48: 390-9.
    Koppelman S, de Jong G, Laaper-Ertmann M, Peeters K, Knulst A, Hefle S, Knol E. Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2. Clin Exp Allergy 2005; 35: 490-7.
    Peeters KA, Koppelman SJ, van Hoffen E, van der Tas CW, den Hartog Jager CF, Penninks AH, Hefle SL, Bruijnzeel-Koomen CA, Knol EF, Knulst AC. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007 Jan;37(1):108-15.
    Flinterman AE, van Hoffen E, den Hartog Jager CF, Koppelman S, Pasmans SG,Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, Knol EF. Children with peanut allergy recognize predominantly Ara h2 and Ara h6, which remains stable over time. Clin Exp Allergy. 2007 Aug;37(8):1221-8.
    Porterfield HS, Murray KS, Schlichting DG, Chen X, Hansen KC, Duncan MW, Dreskin SC. Effector activity of peanut allergens: critical role for Ara h 2, Ara h 6, and their variants. Clin Exp Allergy 2009; 39: 1099-108.
     
    Blanc F, Adel-Patient K, Drumare M, E, Wal J, Bernard H. Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy 2009; 39: 1277-85.
     
    Flinterman AE, Pasmans S, den Hartog Jager CF, Hoekstra MO, Bruijnzeel-Koomen C, Knol EF, van Hoffen E. T cell responses to major peanut allergens in children with and without peanut allergy. Clin Exp Allergy 2010; 40: 590-7.