• 产品编号:CYT-050
    • 产品名称:重组人白介素23/IL 23 Human
    • 产品规格:2ug/10ug/100ug
    • 价  格:700.00/1800.00/
    • 供 应 商:ProSpecbio
    • 库  存:
  • Catalogue Number CYT-050
    Synonyms Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40), NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF2, CLMF p40.
    Introduction IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of interferon-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
    Description IL-23 Human Recombinant produced in HEK 293 cells is a disulfide-linked heterodimer, containing one polypeptide chain p19 subunit containing 169 amino acids and one polypeptide chain IL-12B p40 subunit containing 306 amino acids, with the total molecular weight of 53kDa (not including glycosylation).
    The IL-23 is purified by proprietary chromatographic techniques.
    Source HEK 293 cells.
    Physical Appearance IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder.
    Formulation IL-23 was lyophilized from 10mM Na2PO4, pH 7.5.
    Solubility It is recommended to reconstitute the lyophilized Interleukin-23 in sterile 18M-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
    Stability Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C.
    Please prevent freeze-thaw cycles.
    Purity Greater than 95.0% as determined by analysis by SDS-PAGE.
    Amino acid sequence p19 Subunit: AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
    p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
    Biological Activity The activity, as determined by the dose dependent production of IL-17A from mouse splenocytes and is typically less than 5ng/ml.
    Usage ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.