• 产品编号:C095
    • 产品名称:Cefotiam hydrochloride/盐酸头孢替安
    • 产品规格:50mg/100mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • CAS Number 66309-69-1
    Molecular Formula C18H23N9O4S3 · HCl
    Molecular Weight 562.08 g/mol
    Appearance White powder
    Purity Level ≥98.0%
    Solubility Freely soluble
    Source Semi-synthetic
    Water Content (Karl Fisher) 5.4%
    pH 1.4
    Boiling Point 940 °C
    Flash Point 522.3 °C
    Storage Conditions 2-8 °C

    Description

    Cefotiam HCl is a second generation cephalosporin β-lactam antibiotic.  Cefotiam is soluble in aqueous solution.

    Mechanism

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Spectrum

    Cefotiam is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria. Cefotiam is not effective against Pseudomonas aeruginosa.

    • Microbiology Applications

       

      Cefotiam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

      • Staphylococcus aureus 0.25 µg/ml – 0.5 µg/ml
      • Prevotella bivia 1 µg/ml - >128 µg/ml
      • For a complete list of cefotiam MIC values, click here.