• 产品编号:T005
    • 产品名称:Thiamphenicol/甲砜霉素
    • 产品规格:5g/25g
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • CAS Number 15318-45-3
    Molecular Formula

    C12H15Cl2NO5S

    Molecular Weight 356.22 g/mol
    Form Powder
    Appearance Off-white powder
    Purity Level ≥98.0%
    Solubility Acetonitrile: Soluble
    Alcohol: Soluble
    Dimethylacetamide: Soluble
    Dimethylformamide: Soluble
    Water: Slightly soluble
    Source Synthetic
    Absorbance UV max (95% ethanol): 224, 266, 274 nm (ε 13,700, 800, 700).
    Boiling Point 695.9 °C
    Melting Point 164.3-166.3 °C
    Flash Point 374.7 °C
    Storage Conditions 2-8 °C, protect from light

    Description

    Thiamphenicol is a bacteriostatic antibiotic derived from chloramphenicol. Like chloramphenicol, thiamphenicol is insoluble in water but highly soluble in lipids.

    Mechanism

    Both thiamphenicol and chloramphenicol work by the same mechanism, however, thiamphenicol is about 3X as potent. After entering a bacterial cell, thiamphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to thiamphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

    Spectrum

    Thiamphenicol is a broad spectrum antibiotic commonly used to target bacteria responsible for causing sexually transmitted diseases.

    • Microbiology Applications

      Thiamphenicol is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

      • Neisseria gonorrhoeae 0.125 µg/mL – 4 µg/mL

       

    • Plant Biology Applications

      In a study by Meynier et al. (1989), thiamphenicol was used for hygienic purposes in hybrid walnut propagation.  In addition to other antibiotics used during the study, thiamphenicol was found to be effective against several gram negative pathogenic bacteria.