• 产品编号:A001
    • 产品名称:Actinomycin D/放线菌素D
    • 产品规格:25mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • CAS Number 50-76-0
    Molecular Formula C62H86N12O16
    Molecular Weight 1255.42 g/mol
    Form Powder
    Appearance Red or orange powder
    Purity Level ≥98.0%
    Solubility Acetone: 10 mg/mL
    Acetonitrile: 10 mg/mL
    Water: 0.5 mg/mL
    Source Streptomyces
    Melting Point 243-248 °C
    Storage Conditions -20 °C

    Description

    Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation by acting as a cytotoxic inducer of apoptosis against tumor cells.

    Mechanism

    Actinomycin is a cyclic polypeptide-containing antibiotic that binds to DNA and inhibits RNA polymerase activity. Because Actinomycin can bind DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis. Actinomycin D and its fluorescent derivative,7-aminoactinomycin D (7-AAD), are used as stains in microscopy and flow cytometry applications. The affinity of these stains/compounds for GC-rich regions of DNA strands makes them excellent markers for DNA. 7-AAD binds to single stranded DNA; therefore it is a useful tool in determining apoptosis and distinguishing between dead and alive cells.

    • Plant Biology Applications

      Actinomycin D is used in plant tissue culture to inhibit plant growth through tissue deformation. It also acts as an RNA-synthesis inhibitor. Exposure of Actinomycin D at concentrations of 12-20 ug/ml for 3-4 hours in pea and soybean plants caused significant tissue deformation.

    • Cancer Applications

      Actinomycin-D is used to treat Wilms tumor, rhabdomyosarcoma, germ cell tumors, gestational trophoblastic disease, Ewings sarcoma, testicular cancer, melanoma, choriocarcinoma, neuroblastoma, retinoblastoma, uterine sarcomas, Kaposis sarcoma, sarcoma botryoides and soft tissue sarcoma.